The Niners lead the all-time series between these teams, 32-29, but the Cardinals have won the two most recent meetings. They last faced off in November 2021, with the Cardinals winning in San Francisco, 31-17.
SAN FRANCISCO 49ERS at ARIZONA CARDINALS: The Eagles would probably prefer to see San Francisco miss the playoffs or at least get the lowest possible playoff seed. A Cardinals win also helps to ensure that Arizona remains behind the Saints pick owed to Philly in the draft order. Root for the Cardinals.
Here’s everything you need to know about tonight’s game.
San Francisco 49ers vs Arizona Cardinals
Game time: 8:15 PM EST
Date: Monday, November 21, 2022
Location: Estadio Azteca | Mexico
Radio: Westwood One | SIRIUS: 81 (SF), 85 (ARI), 88 (National) | XM: 226 (SF), 225 (ARI)
Odds courtesy of DraftKings Sportsbook
San Francisco 49ers: -8 (-360)
Arizona Cardinals: +8 (+295)
Over/under: 43.5 points
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