The Colts lead the all-time series between these teams, 26-18, including the past four meetings. They last faced off back in oct. 2017, with Indianapolis pulling off an overtime win at home, 26-23. The last time they played out in California was in 2013, and the Colts pretty much stomped the Niners, 27-7.
There are more than a few familiar faces currently suiting up for the Colts, notably quarterback Carson Wentz and offensive lineman Matt Pryor. Safety Andrew Sendejo missed Indy’s game last week as he worked his way back from a (self-inflicted) concussion, but wasn’t on the team’s injury report late in the week, so there’s a good chance he’ll see playing time. For the 49ers, the team signed and released former Eagles linebacker Mychal Kendricks this week, but they also elevated QB Nate Sudfeld to serve as Jimmy Garoppolo’s backup.
Here’s everything you need to know about tonight’s game.
Indianapolis Colts vs. San Francisco 49ers
Game time: 8:20 PM EST
Date: Sunday, October 24, 2021
Location: Levi’s Stadium | Santa Clara, CA
Radio: SIRIUS: 85 (Ind.), 211 (SF), National (88) | XM: 226 (Ind.), 225 (SF), National (88) | SXM App: 813 (Ind.), 827 (SF), National (88)
Indianapolis Colts: +3.5 (+155)
San Francisco 49ers: -3.5 (-180)
Over/under: 42 points
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