This is a bit of a surprise considering earlier reports indicated Murray was scheduled to play. It would appear Murray's tweaked hamstring may have been giving him some issues while he was warming up in advance of today's Eagles versus Jets game.
Murray's absence now means Ryan Mathews will handle the bulk of Philadelphia's carries. Veteran offensive weapon Darren Sproles will also mix in. Fourth string running back Kenjon Barner might be kept active as extra insurance.
Despite being the team's starting running back, it's hard to say Murray is a huge loss at this point. The 2014 NFL leading rush has only managed to gain 11 yards on 21 carries through two games.
In other news, second-year wide receiver Josh Huff will also reportedly be inactive. Huff was a late addition to the team's injury report on Saturday.