Sam Bradford is officially inactive. Mark Sanchez will start at quarterback, as expected. Thad Lewis will be the backup quarterback.
Starting left tackle Jason Peters is active after being ruled questionable on the final injury report.
Ryan Mathews is out again. Expect the Eagles to rely on DeMarco Murray with Darren Sproles and Kenjon Barner being mixed in.
Zach Ertz is out. Brent Celek will start at tight end. Second-year player Trey Burton will also get more snaps on offense.
Newly promoted wide receiver Jonathan Krause is inactive.
Philadelphia Eagles Inactives List:
Sam Bradford - Injury.
Ryan Mathews - Injury.
Zach Ertz - Injury.
Denzel Rice - Depth DB.
Taylor Hawkinson - Depth OL.
Jonathan Krause - Depth WR.
Brandon Bair - Depth DE.
Detroit Lions Inactives List:
Inactive for #Lions today: LaAdrian Waddle, TJ Jones, Gabe Wright, Corey Robinson, Jermelle Cudjo, Isaiah Johnson, Tim Wright— Tim Twentyman (@ttwentyman) November 26, 2015