1) Sam Bradford versus the New Orleans secondary
The Eagles probably aren't going to find much success on the ground yet again. Not only is Philadelphia's run game bad, but the Saints' run defense is OK. It ranks 12th overall by Football Outsiders. New Orleans' last-ranked secondary is comparatively worse. Bradford is coming off a good game against Washington so maybe he'll be able to build on that performance.
2) Eagles shaky offensive line
Jason Peters and Lane Johnson both said they plan to play this week despite being banged up. Peters is dealing with a quad injury that he tried to play through last week and had to leave the game early. He's officially "questionable" to play. Johnson, meanwhile, is dealing with an MCL injury and an ankle issue. The Eagles have been decent in pass protection so far this season, but the injuries to the tackles could lead to more offensive struggles.
3) Drew Brees
It might be easy to forget how good Brees is considering how bad the Saints have been this year and last. The veteran quarterback is a pain for defenses to deal with. Though he's struggled this season, Brees is coming off his best performance of the season. The veteran's back is up against the wall and he knows he needs to deliver a win here.
4) Former Saints players now on the Eagles
I just get this feeling that either Darren Sproles and/or Malcolm Jenkins is primed to have a big game against their former team. Both players exited New Orleans rather unceremoniously, especially relative to their contributions there. The Saints dumped Sproles in a trade and let Jenkins walk while trying to replace him with an oft-injured and way overpriced free agent in Jairus Byrd. I think both players will tell you that this is "just another game" for them, but deep down they're really a little extra motivated in this one.
5) The struggles of Caleb Sturgis
Philadelphia's new kicker had a terrible debut with the Eagles last week after missing one 33-yard chip shot along with an extra point attempt. Chip Kelly said the Eagles are sticking with Sturgis for now but that might change if the struggles continue.