Starting quarterback Nick Foles is out due to a fractured collarbone. Foles' injury is expected to be re-evaluted in a few weeks. Veteran backup Mark Sanchez will start in place of the injured Foles. Sanchez will be making his first NFL start in nearly two years. He last started under center for the New York Jets in 2012.
With Sanchez starting and Foles out, second-year quarterback Matt Barkley will be the primary backup quarterback. This match-up will mark the first time all season that Barkley is on the active game-day roster. Veteran wide receiver Brad Smith, who is returning from injury this week, will serve as the team's emergency quarter behind Sanchez and Barkley.
Elsewhere, All-Pro offensive lineman Evan Mathis is active for the first team since Week 1. Mathis suffered an MCL sprain against the Jacksonville Jaguars and was placed on the team's injured reserve, designated to return list following the home opener. Mathis' return will give Philadelphia a major boost up front. With Mathis taking over at left guard, Matt Tobin will shift to right guard in order to replace veteran Todd Herremans. Herremans, one of the team's longest-tenured players, was placed on the season-ending injured reserve list earlier in the week.
Speaking of injured reserve, inside linebacker DeMeco Ryans, who suffered an Achilles injury in Week 9, will be replaced by the trio of Casey Matthews, Emmanuel Acho, and first round pick Marcus Smith II. Matthews and Acho will split play-calling duties. Fellow starting inside linebacker Mychal Kendricks handle the responsibility in the team's nickel package.
Starting safety Nate Allen will return to action after sitting out Week 9 due to hamstring injury.
Newly acquired safety Chris Prosinski is active, which is a bit of a surprise. Earl Wolff is a healthy scratch despite starting last week.
Philadelphia Eagles Inactives List:
Nick Foles - Injury.
Earl Wolff - Depth S.
Jaylen Watkins - Depth CB.
Julian Vandervelde - Depth OL.
Dennis Kelly - Depth OL.
Taylor Hart - Depth DE.
Jeff Maehl - Depth WR.
Carolina Panthers Inactives List:
OG Trai Turner
DB Bene Benwikere
WR Philly Brown
RB Chris Ogbonnaya
S Robert Lester
OT David Foucault
T Mike Remmers