The 49ers enter this game as 4.5 point road favorites. San Francisco is on a two-game win streak after having started out the season 1-2. The Rams, meanwhile, have not had win since beating the lowly Tampa Bay Buccaneers in Week 2.
Philadelphia Eagles fans should be rooting for a 49ers loss here. San Francisco is the only team to beat the Eagles this season and they could be in the mix for a NFC playoff spot. Despite almost pulling off a comeback win against the Eagles, the Rams aren't as much of a threat.
A 49ers loss would drop them to 3-3 overall, 0-2 in the division, and 2-3 in the NFC. Can the Rams pull off the upset?
San Francisco 49ers at St. Louis Rams
Game time: 8:30 PM EST
TV schedule: ESPN
Announcers: Mike Tirico, Jon Gruden
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