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There actually is a Saturday night game this week, so we'll start with that one.
Atlanta Falcons at Detroit Lions (+3.5) - My initial gut was to go with the Falcons here, but the trends and simulator like the Lions to cover. Pick: Lions
New Orleans Saints at Dallas Cowboys (-1) - This is a very hard to understand game. All the trends point to a Cowboys cover here, but 57% of the Vegas money is coming in on the Saints. Pick: Cowboys
Tennessee Titans at Green Bay Packers (-12.5) - Hate lines like this so much. Pick: Packers
Indianapolis Colts at Kansas City Chiefs (+7) - Colts are a decent team and the Chiefs stink, but history tells us that 7 point home dogs typically do well. Pick: Chiefs
Buffalo Bills at Miami Dolphins (-4.5) - Pick: Dolphins
San Diego Chargers at New York Jets (-1) - Greg McIlroy starting here really makes this hard to pick. Pick: Jets
Washington Redskins at Philadelphia Eagles (+7) - Basically the same scenario as the Chiefs. The team may be bad, but bad teams cover big spreads at home pretty often. Pick: Eagles
Cincinnati Bengals at Pittsburgh Steelers (-3.5) - Pick: Steelers
St. Louis Rams at Tampa Bay Buccaneers (-3) - Pick: Bucs
Oakland Raiders at Carolina Panthers (-9.5) - Pick: Raiders
New England Patriots at Jacksonville Jaguars (+14.5) - Absurd line. Really like the Jags to cover here. Pick: Jaguars
Minnesota Vikings at Houston Texans (-9.5) - Best RB matchup of the year... maybe decade. Pick: Vikings
Cleveland Browns at Denver Broncos (-13) - Very tough one because of the size of the line. What's worse, all the trends are split. Pick: Broncos
Chicago Bears at Arizona Cardinals (+5.5) - Interesting to note that the Bears & Cards have almost the same record against the spread this year. I fully expect Chicago to let me down here. Pick: Bears
New York Giants at Baltimore Ravens (+1) - Really just picking the winner here. Pick: Giants
San Francisco 49ers at Seattle Seahawks (pick) - Just a straight pick-em here. Pick: Seahawks