North Carolina @ South Carolina - South Carolina should win this one. Clowney is a beast and fun to watch. South Carolina is however annually overrated due to being in the SEC.
USC also plays Hawaii but should stomp on them.
Nicholls State @ Oregon - Because I am huge Ducks homer. Won't be close.
Alabama @ Virginia Tech - Frank Beamers Hokies know how to lose big games.
Georgia @ Clemson - Georgia has a great QB but this game is an easy pick for upset alert. Don't worry though Clemson fans, even if you beat Georgia it is likely you will drop another two games somewhere along the way.
LSU @ TCU - LSU should win unless the game plan involves constantly throwing toward TCU's DBs. The problem LSU faces is a constant identity crisis with their offense. One game they will destroy a team and then forget what they are supposed to do the next game.
Mississippi State @ Oklahoma State. - Oklahoma State should win. MissSU is another decent team that benefits rankings wise from being in the SEC.
Boise State @ Washington - I will give the edge to BSU but only because I do not believe that Sarkisian is a good coach. Really don't like the Donkeys.
Northwestern @ Cal - Why? Cal has a new head coach who likes the pass air raid attack. Could be interesting.
E. Washington @ Oregon State - Why? E Washington is not that far removed from being a power house in their division. Oregon State seems to show up with a different team from one year to the next (really good or really bad)
(Thought about Nevada @ UCLA but Nevada has a new head coach.)